Open AccessPremature Rupture of Fetal Membranes Changes in Collagen Type
Author(s) -
AlZaid N. S.,
Gumaa K. A.,
BouResli M. N.,
Ibrahim M. E. A.
Publication year - 1988
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.1111/j.1600-0412.1988.tb07801.x
Subject(s) - collagenase , amnion , type i collagen , medicine , densitometry , pepsin , fetus , gestational age , premature rupture of membranes , fetal membrane , andrology , pregnancy , biochemistry , enzyme , chemistry , biology , placenta , genetics
Collagen from the chorioamnion units from premature and term pregnancies was solubilized by limited pepsin digestion and subjected to SDS‐PAG electrophoresis. Collagen types were quantitated by densitometry. It was found that collagen type III decreases and collagen type V tends to increase as gestational age advances. Investigating the relative abundance of collagen types at various membrane sites from term pregnancies revealed that type V decreases in the amnion as the rupture site is approached. It is concluded that since type V collagen is more resistant to collagenases, its decrease may predispose that particular site to rupture.