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Risk factors for a non‐favorable outcome after treated E uropean neuroborreliosis
Author(s) -
Eikeland R.,
Mygland Å.,
Herlofson K.,
Ljøstad U.
Publication year - 2013
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2012.01690.x
Subject(s) - medicine , lyme neuroborreliosis , quality of life (healthcare) , neuroborreliosis , depression (economics) , physical therapy , borrelia burgdorferi , immunology , nursing , economics , antibody , macroeconomics
Aim To identify possible risk factors for reduced health‐related quality of life ( HRQ oL) and fatigue after treated L yme neuroborreliosis ( LNB ). Methods We included 50 patients with LNB and analyzed associations between their demographic, clinical, and laboratory characteristics at baseline and outcome at 30 months assessed by the self‐report questionnaires Short Form‐36 ( SF ‐36) and Fatigue Severity Scale ( FSS ). Results Lower scores in the SF ‐36 domain Physical Component Summary were associated with pretreatment symptom duration >6 weeks ( B = −11.0, P = 0.001) and non‐complete recovery at 4 months ( B = −5.5, P = 0.037) ( R 2 = 0.35). Lower scores in the SF ‐36 domain Mental Component Summary were associated with non‐complete recovery at 4 months ( B = −8.9, P = 0.01 ( R 2 = 0.14). Higher FSS scores were associated with pretreatment symptom duration >6 weeks ( B = 1.4, P = 0.006), high scores on the composite clinical score pretreatment ( B = 0.1, P = 0.003), and non‐complete recovery at 4 months ( B = 1.6, P = 0.005) ( R 2 = 0.46). No laboratory test results were associated with these predefined outcomes. Conclusions Delayed treatment start, more symptoms and findings before treatment, and non‐complete recovery at 4 months after treatment are possible predictors of a poorer HRQ oL and more fatigue 30 months after treated LNB . We did not find age, gender, educational level, involvement of the central nervous system, coexisting diseases, or cerebrospinal fluid findings to be associated with reduced HRQ o L or fatigue. Our findings should be replicated in future studies before any conclusions can be drawn.