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Prevalence and profile of sleep disturbances in G uillain‐ B arre S yndrome: a prospective questionnaire‐based study during 10 days of hospitalization
Author(s) -
Karkare K.,
Sinha S.,
Taly A. B.,
Rao S.
Publication year - 2013
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2012.01688.x
Subject(s) - medicine , pittsburgh sleep quality index , anxiety , depression (economics) , sleep disorder , sleep (system call) , hospital anxiety and depression scale , sleep onset latency , psychological intervention , physical therapy , insomnia , pediatrics , psychiatry , sleep quality , computer science , economics , macroeconomics , operating system
Introduction Sleep disturbances in G uillain‐ B arre S yndrome ( GBS ), though common, have not received focused attention. Objectives To study frequency and nature of sleep disturbances in patients with GBS , using validated questionnaires, and analyze the contributing factors. Materials and Methods This prospective study included 60 patients fulfilling N ational I nstitute of N eurological and C ommunicative D iseases and S troke ( NINCDS ) criteria for GBS (mean age: 32.7 ± 12.9 years; median: 30 years; M : F = 46:14), evaluated from 2008 to 2010. Data regarding sleep were collected on 10 consecutive days following admission using R ichard C ampbell S leep score, S t M ary's H ospital S leep Q uestionnaire, and P ittsburgh S leep Q uality I ndex ( PSQI ) and correlated with various possible contributing factors like pain, paresthesia, anxiety, depression, autonomic dysfunctions, severity of disease, and therapeutic interventions among others. Observations Qualitative and quantitative sleep disturbances were rather frequent and involved over 50% patients: abnormal PSQI – 13.3%, abnormal score on R ichard scale – 51.6%, abnormal sleep onset latency – 35%, sleep fragmentation – 40%, and reduced sleep duration – 46.6%. The symptoms were severe during the first week of hospitalization and reduced thereafter. Sleep disturbances as scored on R ichard scale significantly correlated with anxiety, pain, paresthesia, and severity of immobility ( P < 0.05) but not with depression and use of analgesics or antineuritic drugs. Conclusions This study first of its kind suggests that sleep disturbance in GBS is frequent, multi‐factorial, often disturbing, and varies during the course of illness. Routine e nquiry into the sleep disturbances and timely intervention may reduce morbidity and improve their quality of life.