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Animal model for sport‐related concussion; ICP and cognitive function
Author(s) -
Bolouri H.,
Säljö A.,
Viano D. C.,
Hamberger A.
Publication year - 2012
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2011.01614.x
Subject(s) - concussion , cognition , exploratory analysis , traumatic brain injury , medicine , intracranial pressure , morris water navigation task , head injury , psychology , poison control , anesthesia , physical medicine and rehabilitation , injury prevention , neuroscience , surgery , medical emergency , psychiatry , data science , computer science
Bolouri H, Säljö A, Viano DC, Hamberger A. Animal model for sport‐related concussion; ICP and cognitive function.
Acta Neurol Scand: 2012: 125: 241–247.
© 2011 John Wiley & Sons A/S. Background – We have recently developed and characterized a rat model of mild traumatic brain injury which simulates the concussive injuries frequently encountered by players in American professional football. Objectives – To study the effect of multiple impacts to the head on intracranial pressure, cognitive function, and exploratory behavior. Materials and Methods – The model was employed to cause concussion. Intracranial pressure, cognitive function, and exploratory behavior were examined following the multiple impacts of a 50 or 100 g projectile at a velocity of 9.3 or 11.2 m/s to the helmet protected head. Results – Intracranial pressure measured at 6 and 10 h, and 1, 2, 3, 5, and 7 days. It was maximally elevated 10 h after impact and returned to the control levels 7 days later. Morris Water Maze assessment, 48 h after impact, revealed impaired cognitive function. Open field testing 2–4 days and 1 and 2 weeks after impacts indicated consistently reduced spontaneous exploratory activity. Conclusion – Multiple impacts to the head raise intracranial pressure and impair cognitive function and exploratory activity in this animal model.