Premium
Phenytoin‐induced gingival overgrowth
Author(s) -
Arya R.,
Gulati S.
Publication year - 2012
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2011.01535.x
Subject(s) - phenytoin , gingivectomy , medicine , connective tissue , adverse effect , dentistry , gastroenterology , pathology , epilepsy , psychiatry
Arya R, Gulati S. Phenytoin‐induced gingival overgrowth.
Acta Neurol Scand: 2012: 125: 149–155.
© 2011 John Wiley & Sons A/S. Gingival overgrowth is a common adverse effect of therapy with Phenytoin, having important medical and cosmetic implications. Poor periodontal hygiene is an important risk factor for severity of Phenytoin‐induced gingival overgrowth (PIGO), which is a time‐dependent process. There is complex interplay of altered fibroblast biology, connective tissue turnover, inflammatory processes, and growth factors on a background of genetic susceptibility to produce increase in various components of interstitial matrix in PIGO tissue. Treatment options have included change of PHT to another anti‐seizure drug, measures to improve periodontal hygiene and gingivectomy. There is conclusive evidence that folic acid supplementation significantly decreases the incidence of PIGO.