Interleukin 6–174G>C polymorphism and risk of aneurysmal subarachnoid hemorrhage: case–control study and meta‐analysis

Pera J, Dziedzic T, Adamski M, Jagiella J, Krupa M, Moskala M, Szczudlik A, Slowik A. Interleukin 6–174G>C polymorphism and risk of aneurysmal subarachnoid hemorrhage: case–control study and meta‐analysis. 
Acta Neurol Scand: 2012: 125: 111–115. 
© 2011 John Wiley & Sons A/S. Objectives –  Vascular inflammation contributes to the pathogenesis of aneurysmal subarachnoid hemorrhage (aSAH). Interleukin 6 (IL6) is a proinflammatory cytokine involved in many vascular pathologies. Two studies analyzing an association of the functional IL6 gene –174G>C promoter polymorphism with aSAH provided inconsistent results. The aim of this study was to investigate whether this IL6 polymorphism is associated with aSAH in a Polish population. Material and methods –  We genotyped 276 aSAH patients and 581 unrelated control subjects. All were of Caucasian origin. In addition, a meta‐analysis combining results of the current and previously published studies was conducted. Results –  The distribution of IL6 genotypes and alleles did not differ significantly between aSAH (GG – 29.7%, GC – 50.0%, CC – 20.2%, G – 54.7%) and control subjects (GG – 32.0%, GC – 47.3%, CC – 20.7%, G – 44.3%). In the meta‐analysis, the IL6 –174G>C polymorphism was not associated with aSAH risk either. Conclusions –  We failed to find an association between the IL6 ‐174G>C polymorphism and aSAH in analyzed European populations.