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Interleukin 6–174G>C polymorphism and risk of aneurysmal subarachnoid hemorrhage: case–control study and meta‐analysis
Author(s) -
Pera J.,
Dziedzic T.,
Adamski M.,
Jagiella J.,
Krupa M.,
Moskala M.,
Szczudlik A.,
Slowik A.
Publication year - 2012
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2011.01505.x
Subject(s) - subarachnoid hemorrhage , medicine , pathogenesis , meta analysis , interleukin 6 , genotype , proinflammatory cytokine , allele , polymorphism (computer science) , gastroenterology , case control study , gene polymorphism , cytokine , inflammation , gene , genetics , biology
Pera J, Dziedzic T, Adamski M, Jagiella J, Krupa M, Moskala M, Szczudlik A, Slowik A. Interleukin 6–174G>C polymorphism and risk of aneurysmal subarachnoid hemorrhage: case–control study and meta‐analysis.
Acta Neurol Scand: 2012: 125: 111–115.
© 2011 John Wiley & Sons A/S. Objectives – Vascular inflammation contributes to the pathogenesis of aneurysmal subarachnoid hemorrhage (aSAH). Interleukin 6 (IL6) is a proinflammatory cytokine involved in many vascular pathologies. Two studies analyzing an association of the functional IL6 gene –174G>C promoter polymorphism with aSAH provided inconsistent results. The aim of this study was to investigate whether this IL6 polymorphism is associated with aSAH in a Polish population. Material and methods – We genotyped 276 aSAH patients and 581 unrelated control subjects. All were of Caucasian origin. In addition, a meta‐analysis combining results of the current and previously published studies was conducted. Results – The distribution of IL6 genotypes and alleles did not differ significantly between aSAH (GG – 29.7%, GC – 50.0%, CC – 20.2%, G – 54.7%) and control subjects (GG – 32.0%, GC – 47.3%, CC – 20.7%, G – 44.3%). In the meta‐analysis, the IL6 –174G>C polymorphism was not associated with aSAH risk either. Conclusions – We failed to find an association between the IL6 ‐174G>C polymorphism and aSAH in analyzed European populations.