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Autonomic dysfunction in presymptomatic spinocerebellar ataxia type‐2
Author(s) -
MontesBrown J.,
Machado A.,
Estévez M.,
Carricarte C.,
VelázquezPérez L.
Publication year - 2012
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2011.01494.x
Subject(s) - spinocerebellar ataxia , autonomic function , medicine , heart rate variability , valsalva maneuver , cardiology , autonomic nervous system , ataxia , heart rate , psychology , blood pressure , disease , psychiatry
Montes‐Brown J, Machado A, Estévez M, Carricarte C, Velázquez‐Pérez L. Autonomic dysfunction in presymptomatic spinocerebellar ataxia type‐2.
Acta Neurol Scand: 2012: 125: 24–29.
© 2011 John Wiley & Sons A/S. Objectives – To explore and quantify possible abnormalities in the autonomic cardiovascular regulation in presymptomatic stage of type 2 spinocerebellar ataxia (PS‐SCA2). Materials & methods – Heart rate variability (HRV) for 5‐min series of RR intervals was analyzed in 48 PS‐SCA2. Autonomic testing included resting recording , standing , Valsalva maneuver , and deep breathing . The results were compared with a group of sex‐ and age‐matched controls. Results – Time‐and‐frequency domain HRV indices were significantly different between PS‐SCA2 and control groups. Using two standard diagnostic procedures were identified 4 (8.33%) subjects with severe and 8 (16.66%) subjects with early cardiac autonomic neuropathy in PS‐SCA2. CAG index significantly correlated with age (−0.35) and HR (0.31). Conclusions – Our results confirm the presence of cardiovascular autonomic dysfunction in PS‐SCA2 subjects.