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Time course of plasma microparticle concentrations after acute spontaneous basal ganglia hemorrhage
Author(s) -
Dong X.Q.,
Huang M.,
Hu Y.Y.,
Yu W.H.,
Zhang Z.Y.
Publication year - 2011
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2010.01399.x
Subject(s) - basal ganglia , microparticle , microsphere , medicine , basal (medicine) , plasma concentration , chemistry , central nervous system , biology , chemical engineering , engineering , astrobiology , insulin
Dong X‐Q, Huang M, Hu Y‐Y, Yu W‐H, Zhang Z‐Y. Time course of plasma microparticle concentrations after acute spontaneous basal ganglia hemorrhage. Acta Neurol Scand: 2011: 123: 280–288. © 2010 John Wiley & Sons A/S. Objectives – To examine the changes in plasma microparticle (MP) levels in patients after intracerebral hemorrhage (ICH) and assess their association with outcome along with biological markers of the acute phase response. Materials and methods – Thirty healthy controls and 86 patients with acute ICH were recruited. Plasma samples were obtained on admission and at days 1, 2, 3, 5, and 7 after ICH. MPs with procoagulant potential were measured with a prothrombinase assay. Results – Plasma MP levels in patients were substantially higher than those in healthy controls during the 7‐day period. Plasma MP levels were strongly associated with outcome and with biological markers of the acute phase response. Multivariate analysis showed baseline plasma MP level was a good predictor of 1‐week mortality (odds ratio, 1.930; 95% confidence interval, 1.229–3.031; P = 0.004). A receiver operating characteristic curve identified the plasma MP cutoff level (8.4 nmol/l phosphatidylserine equivalent) that predicted 1‐week mortality with high sensitivity (90.6%) and specificity (68.5.0%) ( P < 0.001). Conclusions – Increased membrane microparticle levels occur after ICH and may contribute to the subsequent brain injury, in association with a poor clinical outcome.