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Exercise alleviates Parkinsonism: clinical and laboratory evidence
Author(s) -
Archer T.,
Fredriksson A.,
Johansson B.
Publication year - 2011
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2010.01360.x
Subject(s) - parkinsonism , dopaminergic , parkinson's disease , disease , medicine , physical exercise , quality of life (healthcare) , dopamine , degenerative disease , physical therapy , physical medicine and rehabilitation , psychology , nursing
Archer T, Fredriksson A, Johansson B. Exercise alleviates Parkinsonism: clinical and laboratory evidence.
Acta Neurol Scand: 2011: 123: 73–84.
© 2010 John Wiley & Sons A/S. The present review examines the putative benefits for individuals afflicted with Parkinsonism, whether in the clinical setting or in the animal laboratory, accruing from different exercise regimes. The tendency for patients with Parkinson’s disease (PD) to express either normal or reduced exercise capacity appears regulated by factors such as fatigue, quality‐of‐life and disorder severity. The associations between physical exercise and risk for PD, the effects of exercise on idiopathic Parkinsonism and quality‐of‐life, the effects of exercise on animal laboratory models of Parkinsonism and dopamine (DA) loss following neurotoxic insults, and the effects of exercise on the DA precursor, l ‐Dopa, efficacy are examined. It would appear to be case that in view of the particular responsiveness of the dopaminergic neurons to exercise, the principle of ‘use it or lose’ may be of special applicability among PD patients.