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Acute postoperative seizures after epilepsy surgery – a long‐term outcome predictor?
Author(s) -
Alfstad K. Å.,
Lossius M. I.,
Røste G. K.,
Mowinckel P.,
Scheie D.,
Borota O. C.,
Larsson P. G.,
Nakken K. O.
Publication year - 2011
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2010.01343.x
Subject(s) - epilepsy , medicine , epilepsy surgery , pathological , univariate analysis , multivariate analysis , electroencephalography , surgery , anesthesia , medical record , psychiatry
Alfstad KÅ, Lossius MI, Røste GK, Mowinckel P, Scheie D, Borota OC, Larsson PG, Nakken KO. Acute postoperative seizures after epilepsy surgery – a long‐term outcome predictor?
Acta Neurol Scand: 2011: 123: 48–53.
© 2010 The Authors Journal compilation © 2010 Blackwell Munksgaard. Objectives – The prognostic value of acute postoperative seizures (APS) after epilepsy surgery is much debated. This study evaluated APS, defined as seizures in the first week post‐surgery, as a predictor of long‐term seizure outcome, and investigated the utility of other potential outcome predictors. Materials and methods – Medical records of 48 patients with temporal and extra‐temporal epilepsy surgery were studied. Forty patients had lesional surgery. All had at least 2 year postoperative follow‐up. Results – At 2 year follow‐up, 25 patients (53%) were seizure free. Univariate analysis showed that APS ( P = 0.048), using ≥six AEDs prior to surgery ( P = 0.03), pathological postoperative EEG ( P = 0.043) and female gender ( P = 0.012) were associated with seizure recurrence. Conclusions – Univariate analysis indicate that APS, a high number of AEDs used prior to surgery, and pathological postoperative EEG are possible predictors of seizure recurrence after epilepsy surgery. Only gender retained significance in the multivariate analysis.