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Circulating free nitrotyrosine and cognitive decline
Author(s) -
Coppola L.,
Pastore A.,
Adamo G.,
Coppola A.,
Manzella D.,
Gombos I.,
Luongo M.,
Mastrolorenzo L.
Publication year - 2010
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2009.01286.x
Subject(s) - cognitive decline , cognition , medicine , neuroscience , psychology , psychiatry , disease , dementia
Coppola L, Pastore A, Adamo G, Coppola A, Manzella D, Gombos I, Luongo M, Mastrolorenzo L. Circulating free nitrotyrosine and cognitive decline.
Acta Neurol Scand: 122: 175–181.
© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Objective – To determine if the circulating nitrotyrosine level significantly correlates with parameters measuring cognitive abilities. Materials and methods – One‐hundred and twelve community‐living subjects (ranging in age from 27 to 98 years) were evaluated for cognitive abilities [Mini Mental State Examination (MMSE) score] and circulating free nitrotyrosine plasma level, as well as for several variables that might influence cognitive abilities (age, education) and nitrotyrosine level (body mass index, haematological parameters, cardiovascular and inflammatory indices). Results – In the sub‐group of cognitively impaired subjects (score at MMSE <23.9), but not in that of cognitively not impaired subjects, a significant inverse correlation exists between nitrotyrosine level and MMSE score ( r = −0.378; P < 0.02). Conclusions – The finding, if confirmed by longitudinal studies, could play a role in the management of the subjects with Mild Cognitive Impairment, the clinical condition considered as a transitional state between the changes of cognitive ability in normal aging and dementia.