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Examination of the MSX1 gene in patients with Parkinson’s disease
Author(s) -
Deng H.,
Zhu S. H.,
Le W. D.,
Yang H. R.,
Lv H. W.,
Xu H. B.,
Xie W. J.,
Jankovic J.
Publication year - 2009
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2009.01271.x
Subject(s) - genetics , gene , homeobox , biology , coding region , parkinson's disease , single strand conformation polymorphism , disease , transcription factor , mutation , medicine
Background – Several genetic variants in transcription factor genes have been reported to be associated with Parkinson’s disease (PD). The muscle segment homeobox drosophila homolog of 1 gene ( MSX1 ) is a major upstream regulator of the dopaminergic neuronal subtype specification. Aims of the study – To determine whether genetic variation in the coding region of the MSX1 gene plays a role in the etiology of PD. Methods – We searched for genetic variations in the coding region of the MSX1 gene in 202 patients with PD and 200 normal controls by PCR‐single‐strand conformation polymorphism (PCR‐SSCP) and sequencing. Results – No mutation in the MSX1 gene was identified in our cohort. Conclusions – Mutations in the coding region of the MSX1 gene play little or no role in the development of PD.