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Cerebrospinal fluid metabolite and nigrostriatal dopaminergic function in Parkinson’s disease
Author(s) -
Ishibashi K.,
Kanemaru K.,
Saito Y.,
Murayama S.,
Oda K.,
Ishiwata K.,
Mizusawa H.,
Ishii K.
Publication year - 2010
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2009.01255.x
Subject(s) - homovanillic acid , dopaminergic , cerebrospinal fluid , parkinson's disease , medicine , dopamine transporter , nigrostriatal pathway , dopamine , endocrinology , positron emission tomography , chemistry , neuroscience , psychology , substantia nigra , disease , serotonin , receptor
Ishibashi K, Kanemaru K, Saito Y, Murayama S, Oda K, Ishiwata K, Mizusawa H, Ishii K. Cerebrospinal fluid metabolite and nigrostriatal dopaminergic function in Parkinson’s disease.
Acta Neurol Scand: 2010: 122: 46–51.
© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Objectives – To evaluate the association between cerebrospinal fluid (CSF) homovanillic acid (HVA) concentrations and nigrostriatal dopaminergic function assessed by positron emission tomography (PET) imaging with carbon‐11‐labeled 2β‐carbomethoxy‐3β‐(4‐fluorophenyl)‐tropane ( 11 C‐CFT), which can measure the dopamine transporter (DAT) density, in Parkinson’s disease (PD). Methods – 11 C‐CFT PET scans and CSF examinations were performed on 21 patients with PD, and six patients with non‐parkinsonian syndromes (NPS) as a control group. Results – In the PD group, CSF HVA concentrations were significantly correlated with the striatal uptake of 11 C‐CFT ( r = 0.76, P < 0.01). However, in the NPS group, two indices were within the normal range. Conclusions – In PD, CSF HVA concentrations correlate with nigrostriatal dopaminergic function. Therefore, CSF HVA concentrations may be an additional surrogate marker for estimating the remaining nigrostriatal dopaminergic function in case that DAT imaging is unavailable.