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Autonomic dysfunction in presymptomatic and early symptomatic Huntington’s disease
Author(s) -
Kobal J.,
Melik Z.,
Cankar K.,
Bajrovic F. F.,
Meglic B.,
Peterlin B.,
Zaletel M.
Publication year - 2010
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2009.01251.x
Subject(s) - huntington's disease , disease , medicine , degenerative disease , psychology , neuroscience , psychiatry
Kobal J, Melik Z, Cankar K, Bajrovic FF, Meglic B, Peterlin B, Zaletel M. Autonomic dysfunction in presymptomatic and early symptomatic Huntington’s disease.
Acta Neurol Scand: 2010: 121: 392–399.
© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Objectives – Although autonomic dysfunction was found in advanced Huntington’s disease (HD) patients it is not clear whether there is autonomic dysfunction in presymptomatic and early symptomatic HD. Material & methods – Different cardiovascular autonomic tests were performed in 14 presymptomatic HD mutation carriers (PHD), 11 early symptomatic HD patients (EHD) and in 25 sex and age matched controls. Results – We found attenuated response to simple mental arithmetic test (relative heart rate in PHD and EHD was 10% lower than in controls; diastolic pressure was 10.6% lower in EHD than in controls; P < 0.05) and exaggerated response to the late phase of cold pressor test (relative heart rate was 10% higher in PHD and 7% higher in EHD than in controls; P < 0.05). The rest of the cardiovascular autonomic tests did not reveal significant differences between patients and controls. Conclusions – Our results suggest that subtle autonomic dysfunction occurs even in PHD and EHD.