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Immunoglobulin IgG Fc‐receptor polymorphisms and HLA class II molecules in Guillain–Barré syndrome
Author(s) -
Sinha S.,
Prasad K. N.,
Jain D.,
Nyati K. K.,
Pradhan S.,
Agrawal S.
Publication year - 2010
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2009.01229.x
Subject(s) - allele , human leukocyte antigen , immunology , genotype , biology , medicine , antibody , guillain barre syndrome , receptor , immunoglobulin g , antigen , genetics , gene
Sinha S, Prasad KN, Jain D, Nyati KK, Pradhan S, Agrawal S. Immunoglobulin IgG Fc‐receptor polymorphisms and HLA class II molecules in Guillain–Barré syndrome.
Acta Neurol Scand: 2010: 122: 21–26.
© 2010 The Authors Journal compilation © 2010 Blackwell Munksgaard. Objective – To analyze host genetic factors immunoglobulin G Fc receptors (FcγRs) and human leukocyte antigen (HLA) class II in GBS patients. Methods – FcγRIIA, IIIA and IIIB polymorphisms were studied in 80 each GBS patients and healthy controls by allele specific PCR. HLA class II DRβ1 and DQβ1 typing was performed at the two‐digit level by PCR in randomly selected 54 GBS patients and 202 controls. Results – FcγRIIA‐H/H (56% vs 9%; P < 0.0001) and FcγRIIIA‐V/V (40% vs 13%; P < 0.0001) genotypes, H131 allele frequencies (0.73 vs 0.26, P < 0.0001) and HLA DQβ1*060x (OR, 1.96; 95% CI, 1.26–3.04; P < 0.01) were significantly increased in GBS than controls. DRβ1*0701 alone (OR, 10; 95% CI, 45.90–2.25; P < 0.001) and together with FcγRIIA‐H/H (OR, 11.03; 95% CI, 2.63–46.20; P < 0.001) was significantly associated with GBS patients having microbiological evidence of recent infection. Conclusions – The study indicates that homozygous FcγRIIA and FcγRIIIA genotypes and FcγRIIA H131 allele are associated with GBS. HLA class II molecule DRβ1*0701 is identified as novel genetic risk factor for development of GBS in patients with preceding infection.