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Outcome prediction in traumatic brain injury: comparison of neurological status, CT findings, and blood levels of S100B and GFAP
Author(s) -
Wiesmann M.,
Steinmeier E.,
Magerkurth O.,
Linn J.,
Gottmann D.,
Missler U.
Publication year - 2010
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2009.01196.x
Subject(s) - glasgow coma scale , glial fibrillary acidic protein , traumatic brain injury , medicine , glasgow outcome scale , head trauma , predictive value , diffuse axonal injury , injury severity score , coma (optics) , anesthesia , poison control , surgery , injury prevention , emergency medicine , psychiatry , immunohistochemistry , physics , optics
Wiesmann M, Steinmeier E, Magerkurth O, Linn J, Gottmann D, Missler U. Outcome prediction in traumatic brain injury: comparison of neurological status, CT findings, and blood levels of S100B and GFAP.
Acta Neurol Scand: 2010: 121: 178–185.
© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Objective – To investigate the predictive value of early serum levels of S100B and glial fibrillary acidic protein (GFAP) in traumatic brain injury. Methods – Sixty patients admitted within 24 h of trauma were included. Neurological status on admission (Glasgow Coma Scale), initial cranial computed tomography (CCT) studies (Marshall Computed Tomographic Classification), and outcome after 6 months (Glasgow Outcome Scale) were evaluated. S100B and GFAP levels were determined on admission and 24 h after trauma. Results – Blood levels of S100B and GFAP were elevated following head trauma and quantitatively reflected the severity of trauma. S100B levels after 24 h and on admission were of higher predictive value than CCT findings or clinical examination. GFAP, but not S100B levels rapidly declined after trauma. Conclusions – Blood levels of S100B and GFAP indicate the severity of brain damage and are correlated with neurological prognosis after trauma. Both methods can yield additional prognostic information if combined with clinical and CCT findings.