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The effects of chronic administration of sumatriptan and dipyrone on serotonergic system in the rat brain: an immunohistochemical study
Author(s) -
Genç E.,
Avunduk M. C.,
Oğuz Genç B.,
Saide Şahin A.,
Öz M.
Publication year - 2009
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2008.01153.x
Subject(s) - serotonergic , sumatriptan , serotonin , medicine , saline , analysis of variance , brainstem , 5 ht receptor , midbrain , anesthesia , endocrinology , pharmacology , central nervous system , receptor , agonist
Objective – To investigate the effects of chronic high dose sumatriptan and dipyrone treatment on central serotonergic system in rats. Materials and methods – Male Sprague–Dawley rats (seven per group) were daily injected with sumatriptan (3 mg/kg), dipyrone (400 mg/kg) or saline for 30 days. The brains of animals were surgically removed and immunohistochemically stained for serotonin. Serotonin‐positive stained cells were counted automatically by using a computerized image analysis program. Statistical analysis carried out using one‐way ANOVA followed by post hoc Tukey test. Results – A significant decrease in serotonin‐positive cells in the brainstem was observed after chronic sumatriptan administration while chronic use of dipyrone induced a significant increase in serotonin‐positive cells both in the cortex and midbrain. Conclusion – Our data suggest that central serotonergic system might be modified by chronic use of sumatriptan and dipyrone.