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MR peri‐CSF lesions and CSF oligoclonal bands in Italian multiple sclerosis patients
Author(s) -
Pichiecchio A.,
Tavazzi E.,
Maccabelli G.,
Ponzio M.,
Romani A.,
Schiappacassa R.,
Poloni G. U.,
Franciotta D.,
Roccatagliata L.,
Bergamaschi R.,
Bastianello S.
Publication year - 2009
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2008.01147.x
Subject(s) - multiple sclerosis , medicine , lesion , parenchyma , magnetic resonance imaging , pathology , cerebrospinal fluid , cohort , central nervous system disease , radiology , immunology
Objectives – We investigated the association between brain lesion distribution and the presence of oligoclonal IgG bands (OCBs) in Italian multiple sclerosis (MS) patients. Materials and methods – We retrospectively selected brain magnetic resonance imaging (MRI) uniformly performed in 56 relapsing patients (41 patients OCB positive). Results – Brain lesions in periventricular areas occurred in 92.86% of the patients (100% OCB+ and 73.33% OCB−) ( P = 0.004), but we did not find a significant difference for their median volume ( P = 0.553) and median number ( P = 0.606) between the two groups. Parenchymal lesions occurred in 76.8% of the patients with a similar distribution ( P = 1.00) and no significant difference in the median volume ( P = 0.818) and number ( P = 0.643) between the two groups. Conclusions – The present study on cohort of Italian MS patients demonstrated a lack of correlation between lesion distribution and OCBs, suggesting that B cells producing them could be localized both in meningeal niches and cerebral parenchyma.