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Morphological and immunohistochemical characterization of paraneoplastic cerebellar degeneration associated with Yo antibodies
Author(s) -
Storstein A.,
Krossnes B. K.,
Vedeler C. A.
Publication year - 2009
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2008.01138.x
Subject(s) - immunohistochemistry , pathology , paraneoplastic cerebellar degeneration , antibody , degeneration (medical) , medicine , cerebellar degeneration , cerebellum , autoantibody , immunology
– Immunohistochemical studies of paraneoplastic cerebellar degeneration (PCD) are rare, and the findings vary. Materials and methods – We performed morphological and immunohistochemical characterization of the brain, medulla and tumour of two patients with PCD, Yo antibodies and ovarian adenocarcinoma. Results – The cerebellum of both patients had extensive loss of Purkinje cells. Microglia activation and T cells were found in the cerebellum, but B cells or deposits of IgG or complement were not detected. Microglia activation was also present in the brain stem and medulla. T cells were found in the ovarian adenocarcinoma. Conclusion – PCD is characterized by loss of Purkinje cells and microglia activation, and the presence of T cells indicates cellular immune reactions in PCD and in ovarian cancer.