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Association of low cholesterol with primary intracerebral haemorrhage: a case control study
Author(s) -
Orken D. N.,
Kenangil G.,
Celik M.,
Mail Z.,
Kayaalp H.,
Erginoz E.,
Forta H.
Publication year - 2009
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2008.01083.x
Subject(s) - medicine , cholesterol , incidence (geometry) , epidemiology , intracerebral hemorrhage , primary prevention , gastroenterology , case control study , stroke (engine) , disease , mechanical engineering , physics , subarachnoid hemorrhage , optics , engineering
Objectives – Epidemiological studies have shown that the incidence of intracerebral haemorrhage (ICH) is high in patients with low cholesterol levels. The aim of this study was to investigate the correlation between ICH and low cholesterol in cases of primary ICH. Material and methods – Two hundred and fifty‐nine patients with primary intracerebral haemorrhage and 137 healthy individuals were included in this study. Patients with prior cerebrovascular accident, secondary ICH, hereditary lipid metabolism disorders, thyroid diseases and those using lipid‐lowering drugs were excluded. In all subjects, cholesterol levels were measured after 12 h of fasting. Results – Mean cholesterol levels were 205.8 ± 51.4 mg/dl in the ICH group and 230.2 ± 38.9 mg/dl in the control group. Mean cholesterol levels of patients were significantly lower than the controls ( P < 0.000). In ICH group, the frequency of patients who had very low cholesterol levels was significantly higher than the control group ( P < 0.000). Conclusions – Individuals with lower cholesterol levels have an increased risk of ICH. Therefore, before treatment with statins, clinicians must be aware of the possible ICH risk.