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The neuroprotective role of erythropoietin in the management of acute ischaemic stroke: from bench to bedside
Author(s) -
Ntaios G.,
Savopoulos C.,
Chatzinikolaou A.,
Hatzitolios A. I.
Publication year - 2008
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2008.01039.x
Subject(s) - erythropoietin , neuroprotection , medicine , stroke (engine) , bench to bedside , ischaemic stroke , clinical trial , intensive care medicine , pharmacology , ischemia , medical physics , mechanical engineering , engineering
Recombinant human erythropoietin was produced soon after the discovery of the erythropoietin gene in 1985 and since then, it is used in various clinical conditions such as chronic renal failure. Moreover, experimental studies have shown that erythropoietin exerts neuroprotective action as well. Recently, a clinical trial yielded promising results concerning the use of erythropoietin in stroke management. In this review, we summarize the main data which suggest that recombinant human erythropoietin and its analogues may indeed have a role in stroke treatment.