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Multiple alpha‐synuclein gene polymorphisms are associated with Parkinson’s disease in a Norwegian population
Author(s) -
Myhre R.,
Toft M.,
Kachergus J.,
Hulihan M. M.,
Aasly J. O.,
Klungland H.,
Farrer M. J.
Publication year - 2008
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2008.01019.x
Subject(s) - genetics , linkage disequilibrium , single nucleotide polymorphism , biology , haplotype , allele , genetic association , population , gene , parkinson's disease , genetic marker , genotype , disease , medicine , pathology , environmental health
Objectives – Previous studies have found associations between Parkinson’s disease (PD) and polymorphisms located within both the alpha‐synuclein gene ( SNCA ) promoter and other gene regions. Our aim was to study SNCA gene markers in a closely matched Norwegian PD population to examine the genetic relationship between different polymorphisms associated with the disease. Methods – We genotyped seven single nucleotide polymorphisms (SNPs) located in the SNCA promoter and two SNPs in the 3′ gene region and seven microsatellite markers located across the gene in a closely matched series of 236 PD patients and 236 controls. Linkage disequilibrium (LD) structure was examined, and association of single markers and gene haplotypes analyzed. Results – Several markers located across the SNCA gene were associated with PD, including marker alleles associated with disease in previous studies (Rep1 263‐bp allele, rs356165 and rs356219). Conclusion – LD between associated marker alleles located across the SNCA gene suggests that a single genetic effect might explain the previous reported association in the promoter and 3′ regions.