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Long‐term assessment of oxcarbazepine in a naturalistic setting: a retrospective study
Author(s) -
Seneviratne U.,
D’Souza W.,
Cook M.
Publication year - 2008
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2007.00951.x
Subject(s) - oxcarbazepine , medicine , retrospective cohort study , confidence interval , retention rate , epilepsy , cohort , partial epilepsy , pediatrics , anesthesia , carbamazepine , psychiatry , computer security , computer science
Background – New antiepileptics seem to be better tolerated by patients. The retention rate of an antiepileptic would be a useful indicator of its practical usefulness. Aims – To assess the long‐term outcome of oxcarbazepine (OXC) in a naturalistic setting by determining the retention rate. Methods – This is a retrospective study. All epilepsy patients treated with OXC at a tertiary care epilepsy center during a period of 3.5 years were included in this study. Retention rates of OXC at 1 and 3 years were estimated for each cohort group using Kaplan–Meier estimates and corresponding 95% confidence intervals. Results – A total of 98 patients were studied. OXC was used as monotherapy in 14 (14.3%) and as add‐on therapy in 84 (85.7%). The mean daily dose was 947 ± 492 mg and 60% received ≤900 mg/day. Using the Kaplan–Meier survival analysis, the retention rates of OXC at 1 and 3 years were estimated to be 0.853 (0.749–0.956) and 0.737 (0.570–0.904), respectively. Conclusions – OXC is well tolerated by patients as both monotherapy and add‐on therapy.