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CSF biomarkers in the evaluation of idiopathic normal pressure hydrocephalus
Author(s) -
ÅgrenWilsson A.,
Lekman A.,
Sjöberg W.,
Rosengren L.,
Blennow K.,
Bergenheim A. T.,
Malm J.
Publication year - 2007
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2007.00890.x
Subject(s) - cerebrospinal fluid , medicine , normal pressure hydrocephalus , hydrocephalus , lumbar , tau protein , encephalopathy , pathology , cardiology , gastroenterology , alzheimer's disease , surgery , dementia , disease
Background – To evaluate cerebrospinal fluid (CSF) markers for neuronal degeneration and demyelination in idiopathic normal pressure hydrocephalus (INPH), subcortical arteriosclerotic encephalopathy (SAE), and neurologically healthy subjects. Methods – Lumbar CSF concentrations of sulfatide, neurofilament protein light (NFL), total‐tau (T‐tau), hyperphosphorylated tau (P‐tau), and beta‐amyloid 1–42 (Aβ42) were analyzed in 62 INPH patients, 26 SAE patients, and 23 neurologically healthy controls. In INPH patients, samples before and after shunt surgery were analysed. Results – The CSF concentration of NFL was elevated in INPH and SAE compared with the controls, and levels of T‐tau, P‐tau, and Aβ42 were lower in INPH compared with SAE and controls. No difference was seen for sulfatide. All markers except Aβ42 were significantly elevated after shunt surgery. Conclusions – The most striking finding was the power of the combined pattern of NFL, P‐tau, and Aβ42 in distinguishing between the clinical diagnoses of INPH, SAE, and neurologically healthy elderly.