Premium
The APOE polymorphism and 1‐year outcome in ischemic stroke: genotype–gender interaction
Author(s) -
Gromadzka G.,
BaranskaGieruszczak M.,
SarzynskaDlugosz I.,
Ciesielska A.,
Czlonkowska A.
Publication year - 2007
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2007.00880.x
Subject(s) - apolipoprotein e , genotype , medicine , stroke (engine) , allele , disease , gene , genetics , biology , mechanical engineering , engineering
Objective – In human genetic studies an effect of the apolipoprotein E gene ( APOE ) polymorphism on the risk, course and prognosis in chronic and acute nervous system disorders was established. We aimed to evaluate whether the APOE genotype is related to acute neurological impairments due to ischemic stroke (IS), and to outcomes (up to 1 year) indicated by severe functional disability, dependence in daily living or death. Materials and methods – A total of 657 patients (326 men, 331 women), divided into the three groups: E2 ( APOE ε2/ε3 subjects), E3 ( APOE ε3/ε3 subjects), and E4 ( APOE ε3/ε4 and ε4/ε4 subjects), were analyzed. Results – There was no association between the APOE genotype and baseline clinical characteristics, severity of neurological impairments during acute stroke, and 1‐year outcome, when analyzing whole patient population. APOE gene interacted with gender in predicting severity of acute neurological deficit and post‐stroke mortality within the period up to 1 year after the IS. Gender‐stratified analysis indicated the E4 genotype as a significant independent positive predictor of death within 1 year after stroke incidence in men patients. Conclusion – Ischemic stroke severity and outcome may be affected by complex interactions between gender and genetic factors that warrant further exploration.