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Constant blood flow reduction in premotor frontal lobe regions in ALS with dementia – a SPECT study with 3D‐SSP
Author(s) -
Ishikawa T.,
Morita M.,
Nakano I.
Publication year - 2007
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2007.00876.x
Subject(s) - cerebral blood flow , frontal lobe , amyotrophic lateral sclerosis , perfusion , nuclear medicine , single photon emission computed tomography , dementia , blood flow , medicine , psychology , cardiology , neuroscience , disease
Objectives – We investigated the regional cerebral blood flow in amyotrophic lateral sclerosis with dementia (ALS‐D) patients, using single photon emission computed tomography (SPECT). Materials and methods – The 123 I‐IMP SPECT data for 5 ALS‐D and 16 ALS patients were analyzed using three‐dimensional stereotactic surface projection (3D‐SSP). Results – 3D‐SSP demonstrated marked prefrontal hypoperfusion in all the five ALS‐D cases and significant bilateral prefrontal hypoperfusion in group comparisons. Conclusions – This study revealed prefrontal hypoperfusion in ALS‐D cases to be an obvious abnormality with scientific objectivity.