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Oxygen metabolism changes in patients with idiopathic normal pressure hydrocephalus before and after shunting operation
Author(s) -
Miyamoto J.,
Tatsuzawa K.,
Inoue Y.,
Imahori Y.,
Mineura K.
Publication year - 2007
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2007.00798.x
Subject(s) - normal pressure hydrocephalus , medicine , hydrocephalus , oxygen , neurosurgery , oxygen pressure , oxygen metabolism , shunting , positron emission tomography , shunt (medical) , anesthesia , hypoxia (environmental) , surgery , cardiology , nuclear medicine , dementia , chemistry , disease , organic chemistry
Objective – The present study revealed the changes in cerebral oxygen metabolism before and after ventriculo‐peritoneal shunt (VPS) using 15 O positron emission tomography ( 15 O‐PET). Methods – Eight patients with idiopathic normal pressure hydrocephalus (i‐NPH) underwent VPS. A 15 O‐PET study was undertaken before and approximately 3 months after VPS. In five patients, the symptoms improved based on the classification by Krauss et al. [Neurosurgery 1996; 39 :292] (good responders) after VPS. In three patients, the symptoms improved subjectively following VPS (poor responders). The changes in oxygen metabolism before and after VPS were analyzed. Results – The postoperative regional cerebral metabolic rate of oxygen (rCMRO 2 ) of the good responders increased significantly. The postoperative regional oxygen extraction fraction (rOEF) is reduced in the poor responders. Conclusion – The improvement of rCMRO 2 correlated with the response to VPS. Significant changes in rOEF might predict poor response to VPS.