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The apolipoprotein E ɛ 4‐allele and antihypertensive treatment are associated with increased risk of cerebral MRI white matter hyperintensities
Author(s) -
Høgh P.,
Garde E.,
Mortensen E. L.,
Jørgensen O. S.,
Krabbe K.,
Waldemar G.
Publication year - 2007
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2006.00779.x
Subject(s) - hyperintensity , medicine , white matter , apolipoprotein e , magnetic resonance imaging , cardiology , disease , radiology
Objective – Apolipoprotein E‐ ɛ 4 (APOE‐ ɛ 4) is a potential risk factor for cerebral vascular disease. The aim of the present study was to examine the relative importance of APOE‐ ɛ 4 and other relevant risk factors for the extent of cerebral white matter hyperintensity (WMH) in a community‐based sample of elderly subjects. Materials and methods – From a cohort of 976 subjects born in 1914, APOE genotype was determined and MRI examinations were carried out in 75 subjects. WMH were rated using a standard semi‐quantitative method. ANOVA and regression analyses were conducted to explore the relative importance of the potential risk factors. Results – APOE genotype and antihypertensive treatment were significantly associated with severity of total WMH load ( P < 0.05). Conclusions – The study confirmed the association between APOE‐ ɛ 4 and WMH. Pharmaceutical treatment for arterial hypertension was also associated with the total burden of WMH in this study.