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Cerebrospinal fluid protein reactions during non‐neurological surgery
Author(s) -
Anckarsäter R.,
Vasic N.,
Jidéus L.,
Kristiansson M.,
Zetterberg H.,
Blennow K.,
Anckarsäter H.
Publication year - 2007
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2006.00741.x
Subject(s) - cerebrospinal fluid , medicine , albumin , csf albumin , anesthesia , serum albumin , central nervous system , blood–brain barrier , inflammation , cerebral spinal fluid , c reactive protein , surgery , gastroenterology
Objective – To study changes in cerebrospinal fluid (CSF) protein markers of blood–CSF barrier integrity and immunological reactions during surgical stress. Subjects and methods – Thirty‐five patients without neurological or psychiatric disorders undergoing knee replacements had CSF and serum samples drawn from spinal and arterial catheters before, 3 h after and the morning after surgery. Results – Serum albumin decreased during surgery and CSF albumin decreased during and after surgery, and, as a consequence, the CSF/serum albumin ratio decreased significantly during the study period, especially after the intervention. In contrast, CSF concentrations of beta‐2‐microglobuline ( β 2M) increased significantly during surgery and remained high. The CSF general marker beta‐trace protein ( β TP) remained unchanged. Conclusions – Central nervous system protein reactions to a non‐neurological surgical intervention include sharply decreased permeability of albumin into the CSF and signs of intrathecal inflammatory activity.