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Psychiatric disorders appear equally in patients with myotonic dystrophy, facioscapulohumeral dystrophy, and hereditary motor and sensory neuropathy type I
Author(s) -
Kalkman J. S.,
Schillings M. L.,
Zwarts M. J.,
Van Engelen B. G. M.,
Bleijenberg G.
Publication year - 2007
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2006.00737.x
Subject(s) - comorbidity , medicine , myotonic dystrophy , psychiatry , psychiatric interview , psychopathology , depression (economics) , beck depression inventory , physical therapy , anxiety , economics , macroeconomics
Objectives – To study the presence of psychiatric comorbidity assessed by the use of a structured clinical interview and self‐reported questionnaires in a large sample of patients with adult‐onset myotonic dystrophy (DM), facioscapulohumeral muscular dystrophy (FSHD), and hereditary motor and sensory neuropathy type I (HMSN‐I), and to assess whether psychiatric comorbidity is related to fatigue severity and/or muscle strength. Methods – In a cohort of 217 patients with a neuromuscular disorder (79 DM, 65 FSHD and 73 HMSN‐I patients) overall psychiatric comorbidity was studied cross‐sectionally with the structured clinical interview for DSM‐IV axis I disorders. Self‐reported psychopathology, fatigue severity and muscle strength were assessed with the Beck Depression Inventory, Symptom Checklist‐90, General Health Questionnaire‐12, Checklist Individual Strength and muscle strength [Medical Research Council (MRC)‐scale]. Results – In all three neuromuscular disorders (DM, FSHD and HMSN), 10–12% of the patients met DSM IV clinical criteria for current psychiatric disorders. Lifetime psychiatric disorders were found in 32% of patients in all three patient groups. The most common psychiatric disorders were depression and phobias. A comparison of patients with and without current psychiatric disorder showed that fatigue severity and muscle strength (MRC) were not related to psychiatric comorbidity. Conclusion – Psychiatric disorders appear equally in patients with DM, FSHD and HMSN‐I and are not related to fatigue or muscle strength in these patients.