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ACE I/D polymorphism in different etiologies of ischemic stroke
Author(s) -
Pera J.,
Slowik A.,
Dziedzic T.,
Wloch D.,
Szczudlik A.
Publication year - 2006
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2006.00672.x
Subject(s) - etiology , genotype , stroke (engine) , medicine , allele , polymorphism (computer science) , ischemic stroke , disease , gastroenterology , population , angiotensin converting enzyme , genetics , gene , biology , ischemia , blood pressure , mechanical engineering , environmental health , engineering
Objectives – Data concerning an association between angiotensin‐converting enzyme ( ACE ) gene insertion/deletion (I/D) polymorphism and ischemic stroke (IS) remain inconsistent. Results of some studies suggest that DD genotype may be a risk factor for small vessel disease (SVD) stroke. Here, we investigated whether this polymorphism is associated with IS of different etiologies in a Polish population. Subjects and methods – Ischemic stroke etiology was established according to the TOAST criteria. We studied 92 stroke patients with large vessel disease and their 184 matched controls; 96 stroke patients with SVD and 192 controls; 180 patients with cardioembolic stroke (CE) and 180 controls. ACE I/D polymorphism was determined using the polymerase chain reaction method. Results – The distribution of ACE genotypes and alleles was essentially the same in all analyzed IS subtypes and their matched controls. Conclusions – We failed to find an association between ACE polymorphism and etiological subtypes of IS in a Polish population.