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Subclinical left ventricular dysfunction in multiple sclerosis
Author(s) -
Akgül Ferit,
Mclek İsmet,
Duman Taşkın,
Seyfelì Ergün,
Seydaliyeva Tunzale,
Yalçın Fatih
Publication year - 2006
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2006.00662.x
Subject(s) - cardiology , subclinical infection , medicine , ejection fraction , asymptomatic , diastole , clinical significance , statistical significance , multiple sclerosis , heart failure , blood pressure , psychiatry
Objectives – To investigate the left (LV) and right ventricular (RV) function in multiple sclerosis (MS) using standard echocardiography and Doppler tissue imaging (DTI). Materials and methods – A total of 41 patients with definite MS and 32 healthy controls were included in the study. Results – LV end‐systolic dimension was increased and LV ejection fraction was decreased in MS patients compared with controls ( P <0.05). LV end‐diastolic dimension was increased in MS patients, however, did not reach significance. Among DTI parameters, mitral annular peak early diastolic velocity to peak late diastolic velocity ratio (Em/Am) was decreased in MS patients, but not reach statistical significance. No significant differences in tricuspid annular Em/Am ratio was found between MS patients and controls. A statistically significant increase of DTI derived LV myocardial performance index was found in MS patients as compared with controls. RV myocardial performance index showed a tendency to be increased in MS patients, however, did not reach significance. Conclusions – These findings suggest subclinical LV dysfunction and preserved RV function in patients with MS.