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An immunprecipitation assay for the detection of onconeural antibodies
Author(s) -
Monstad S. E.,
Vedeler C. A.
Publication year - 2006
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2006.00622.x
Subject(s) - antibody , medicine , immunoassay , immunohistochemistry , monoclonal antibody , immune system , pathology , immunology
– Onconeural antibodies are found in some patients with cancer, and are associated with paraneoplastic neurological syndromes. Method – A multi‐well adapted fluid‐phase immunoassay using radiolabelled recombinant onconeural proteins for the detection of onconeural antibodies is described. Result and Conclusion – This immunoprecipitation technique is more sensitive in detecting onconeural antibodies than immunohistochemistry and immune blots.