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Autopsy findings in the nervous system and ovarian tumour of two patients with paraneoplastic cerebellar degeneration
Author(s) -
Storstein A.,
Krossnes B.,
Vedeler C. A.
Publication year - 2006
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2006.00621.x
Subject(s) - paraneoplastic cerebellar degeneration , autopsy , cerebellum , cerebellar degeneration , pathology , degeneration (medical) , medicine , central nervous system , ovarian cancer , nervous system , cancer , immunology , antibody , autoantibody , psychiatry
Objectives. To review autopsy findings in paraneoplastic cerebellar degeneration. Materials and methods. We report the autopsy results of two individuals with paraneoplastic cerebellar degeneration and ovarian cancer. Results. Both patients had extensive loss of cerebellar Purkinje cells and general activation of microglia in the central nervous system, as well as signs of immunactivation in the medulla. Conclusion. The immunoactivation in PCD is widespread and involving more than the cerebellum.