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Fc γ R and multiple sclerosis: an overview
Author(s) -
Torkildsen Ø.,
Vedeler C. A.,
Nyland H. I.,
Myhr K.M.
Publication year - 2006
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2006.00619.x
Subject(s) - immunology , multiple sclerosis , immune system , disease , medicine , antibody , biology , pathology
Receptors for the Fc domain of IgG (Fc γ R) play a key role in the immune system by linking the cellular and humoral immune systems. Despite extensive documentation of CNS‐specific antibodies in cerebrospinal fluid and plaques in multiple sclerosis (MS) patients, the role of Fc γ R in this disease remains largely unexplored. Studies indicate however, that polymorphisms in some Fc γ R genes and treatment that induces Fc γ R on immune‐competent cells could influence disease progression and treatment response.