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Anti‐tissue transglutaminase IgA antibodies in peripheral neuropathy and motor neuronopathy
Author(s) -
Matà S.,
Renzi D.,
Pinto F.,
Calabrò A.
Publication year - 2006
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2006.00602.x
Subject(s) - polyneuropathy , tissue transglutaminase , medicine , antibody , peripheral neuropathy , peripheral , chronic inflammatory demyelinating polyneuropathy , peripheral nerve , guillain barre syndrome , disease , pathology , immunology , gastroenterology , enzyme , endocrinology , biology , anatomy , biochemistry , diabetes mellitus
Objectives – The aim of the study was to investigate the occurence of anti‐tissue transglutaminase antibodies (tTGA) in peripheral nerve disorders, and to correlate them with neurophysiologic findings and anti‐glycolipid antibodies. Materials and methods – We examined tTGA immunoglobulin‐A serum level from 220 patients with polyneuropathy (acute inflammatory: n = 90; chronic inflammatory: n = 56; non‐inflammatory: n = 74) and 110 with motor neuron disease (MND). Results – Seven of the 330 neurologic patients (2.1%, six with polyneuropathy and one with MND) were positive for tTGA. Sixty‐one of the 330 neurologic patients (18.4%) had slightly increased tTGA values compared with healthy controls. Increased tTGA values were associated with greater impairment of neurophysiologic findings, but not with the presence of anti‐glycolipid antibodies. Conclusions – We found a high prevalence of tTGA reactivity in patients with peripheral nerve disorders or MND. However, we were unable to demonstrate an increased risk of celiac disease in these diseases.