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White matter hyperintensities and cortical acetylcholinesterase activity in parkinsonian dementia
Author(s) -
Marshall G. A.,
Shchelchkov E.,
Kaufer D. I.,
Ivanco L. S.,
Bohnen N. I.
Publication year - 2006
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2005.00553.x
Subject(s) - hyperintensity , dementia , acetylcholinesterase , white matter , neuroscience , medicine , psychology , disease , magnetic resonance imaging , biology , biochemistry , radiology , enzyme
Objective – To investigate the relationship between the severity of white matter hyperintensities (WMH) and cortical acetylcholinesterase (AChE) activity in parkinsonian dementia (PDem). Methods – PDem ( n = 11) and control subjects ( n = 14) underwent [ 11 C]methyl‐4‐piperidinyl propionate ( 11 C‐PMP) AChE brain positron emission tomography and magnetic resonance (MR) imaging. Presence of WMH on proton density and T2 MR images was scored using a modified version of the semi‐quantitative rating scale by Scheltens et al. [ J Neurol Sci 114 (1993)]. Results – Analysis demonstrated significantly lower mean cortical 11 C‐PMP k3 hydrolysis rates in PDem (−19.9%) when compared with control subjects ( P < 0.0001). PDem subjects had higher mean severity of WMH (+20.1%) when compared with control subjects ( P < 0.05). When WMH severity was entered into the analysis of variance model, there was no significant co‐variate effect on cortical AChE activity ( F = 0.24, ns). Conclusions – The concomitant presence of mild to moderate WMH in patients with PDem does not have a significant effect on cortical AChE activity.