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Convulsive episodes in patients with group A xeroderma pigmentosum
Author(s) -
Kohyama J.,
Furushima W.,
Sugawara Y.,
Shimohira M.,
Hasegawa T.,
Hayashi M.,
Moriwaki S.,
Iwakawa Y.
Publication year - 2005
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2005.00478.x
Subject(s) - xeroderma pigmentosum , incidence (geometry) , convulsion , epilepsy , medicine , pediatrics , dermatology , psychiatry , biology , genetics , dna repair , physics , gene , optics
Objectives – To clarify the incidence of convulsive episodes in patients with group A xeroderma pigmentosum (XPA). Materials and methods – By investigating the history of convulsive episodes of our 33 XPA patients through either their medical charts or direct interviews with their caretakers. Results – Five patients had several episodes of afebrile convulsion at ages older than 12. With the exception of one patient who began to show convulsive episodes at 13, no other XPA patients exhibited febrile seizures. As far as our 33 XPA patients were concerned, 15% exhibited epilepsy, and 3% experienced febrile seizures. Conclusions – Japanese XPA patients showed a lower incidence of febrile seizures, while exhibiting a higher incidence of epilepsy. It is assumed that the brain of young patients with XPA is difficult to develop convulsions.