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Lumbar infusion test in normal pressure hydrocephalus
Author(s) -
Kahlon B.,
Sundbärg G.,
Rehncrona S.
Publication year - 2005
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2005.00417.x
Subject(s) - normal pressure hydrocephalus , medicine , lumbar , shunt (medical) , surgery , hydrocephalus , anesthesia , shunting , urology , dementia , disease
Objective – To compare potential clinical value of plateau pressure ( P pl ), resistance to outflow ( R out ), pulse‐pressure amplitude ( P plA ) and rate of pressure increase ( v P ), taken from the constant rate lumbar infusion test (LIT), as predictors for the outcome of shunt surgery. Methods – Recordings from preoperative LIT in 55 patients were scrutinized for the values of P pl , P plA , v P and R out . Gait, memory, spatial capacity and reaction ability were tested before and 6 months after shunt surgery. Results – Forty‐three (78%) of the patients improved. There were no statistically significant differences in P pl , R out , P plA or v P between improved and not improved patients. Five patients with P pl below 22 mmHg (the cut off level) improved after shunting, while 16 and eight patients with R out below the cut off levels of 18 and 14 mmHg/ml/min improved. P plA correlated with P pl and R out ( r = 0.74 and 0.63, respectively). In the group of patients with high P plA (≥20 mmHg) as many as 93% improved but a high P plA did not recruit more improved patients than P pl or R out alone. Conclusion – vPor P plA does not add useful information to P pl for selecting patients with suspected NPH for surgery. R out calculations from LIT does not provide advantage over using the steady‐state plateau pressure for selecting patients for surgery and may increase the risk of missing patients who should benefit from surgery.