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G309D and W437OPA PINK1 mutations in Caucasian Parkinson's disease patients
Author(s) -
Deng H.,
Le W. D.,
Zhang X.,
Pan T. H.,
Jankovic J.
Publication year - 2005
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2005.00383.x
Subject(s) - pink1 , mutation , parkinson's disease , genetics , medicine , disease , gene mutation , gene , population , degenerative disease , parkin , biology , environmental health
Objective – To determine whether the G309D and W437OPA mutations in PINK1 gene are present in American Caucasian population of patients with Parkinson's disease (PD). Methods – We searched for the G309D and W437OPA mutation by sequencing the regions of interest in the PINK1 gene in 237 unrelated Caucasian patients. Results – None of the 237 samples showed the G309D or W437OPA mutations. Conclusions – The G309D and W437OPA mutations in PINK1 gene probably do not represent common causes of familial or sporadic PD in a Caucasian population.