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Multiple sclerosis: long‐term remission after a high dose of cyclophosphamide
Author(s) -
Bittencourt P. R. M.,
GomesdaSilva M. M.
Publication year - 2005
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2005.00340.x
Subject(s) - cyclophosphamide , multiple sclerosis , medicine , complete remission , magnetic resonance imaging , chemotherapy , spontaneous remission , disease , surgery , oncology , pediatrics , radiology , pathology , immunology , alternative medicine
The objective of this case report is to document the possibility that immunoablative doses of cyclophosphamide may provide a long‐term remission of multiple sclerosis (MS). We report the case of a 48‐year‐old woman with definite MS diagnosed in 1994 who has been in complete remission since a dose of 3800 mg of cyclophosphamide was accidentally given intravenously in early 1997. For 7 years there have been no signs of disease activity on history, physical examination, or on high‐quality magnetic resonance imaging (MRI) with appropriate contrast‐enhancement methodology. This case includes information on the possibility that less aggressive chemotherapy than that used with stem cell transplantation may be effective in the long‐term control of MS.