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The antibodies against Bordetella pertussis in sera of patients with Parkinson's disease and other non‐neurological diseases
Author(s) -
Fiszer U.,
Tomik B.,
Grzesiowski P.,
KrygowskaWajs A.,
Walory J.,
Michałowska M.,
Palasik W.
Publication year - 2004
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.2004.00285.x
Subject(s) - bordetella pertussis , medicine , immunology , antibody , whooping cough , pertussis toxin , population , vaccination , biology , bacteria , genetics , receptor , environmental health , g protein
Objectives – It has been reported that the prevalance of parkinsonism might be associated with exposure to whooping cough. Methods – Examination of levels of antibodies against Bordetella pertussis in serum using enzyme‐linked immunosorbent assay (ELISA) tests [presence of IgG antibodies against filamentous hemagglutinin and pertussis toxin (PT)] were performed in 81 persons (including 45 patients with controls) (age‐matched groups). Results – Positive results were found in patients with Parkinson's disease (PD), patients with other non‐inflammatory diseases, and controls (about 40–45% in each group). A detailed examination of separate responses (IgG and IgA antibodies against PT, and a whole cell immune response) and of the serum level of immunoglobulins IgG, IgA and IgM was also performed. Conclusion – Our results demonstrate numerous cases of whooping cough serum antibodies among the adult population (also among PD patients). The results of our research, i.e. a common occurrence of Bordetella pertussis infection do not provide evidence of relationship between PD and the above‐mentioned infection.