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White matter hyperintensities on MRI in a patient with corticobasal degeneration
Author(s) -
Doi T.,
Iwasa K.,
Makifuchi T.,
Takamori M.
Publication year - 1999
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1999.tb07345.x
Subject(s) - corticobasal degeneration , hyperintensity , white matter , magnetic resonance imaging , progressive supranuclear palsy , dystonia , medicine , myoclonus , atrophy , pathology , psychology , neuroscience , radiology
We describe a patient who presented with the clinicopathological features of corticobasal degeneration (CBD). Over the course of 8 years, the patient developed myoclonus, dystonia, and supranuclear gaze palsy associated with an akinetic‐rigid syndrome. To our knowledge, no previous report of a patient with CBD has described clear‐cut regional white matter changes as revealed by magnetic resonance imaging (MRI) scans. In our patient, a T 2 ‐weighted MR image of the brain showed focal atrophy of the bilateral frontal cortex and asymmetric regional hyperintensities of the subjacent white matter. These signal changes seemed to primarily reflect the progression of neuronal degeneration, especially the demyelination secondary to axonal loss or change.