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Effect of nimodipine on cerebral blood flow and cerebrovascular reactivity after subarachnoid haemorrhage
Author(s) -
Rasmussen G.,
Bergholdt B.,
Dalh B.,
Sunde N.,
Cold G.,
Voldby B.
Publication year - 1999
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1999.tb07341.x
Subject(s) - nimodipine , hyperventilation , cerebral blood flow , anesthesia , medicine , autoregulation , subarachnoid hemorrhage , cerebral autoregulation , intracranial pressure , blood pressure , calcium
The aim of the present study was to investigate the effect of nimodipine on autoregulation of cerebral blood flow (CBF), CO 2 reactivity and cerebral oxygen metabolism (CMRO 2 ) in patients with subarachnoid haemorrhage (SAH). Eight patients with severe SAH were studied with repeated CBF and CMRO 2 measurements on the first day of the bleeding and after at least 12 h of treatment of nimodipine. An initial resting study, an autoregulation study and a hyperventilation study was performed. CBF was measured using the 133‐Xenon intravenous method. CMRO 2 was calculated as AVDO 2 x CBF. Nimodipine did not significantly change CBF and CMRO 2 in the initial resting study. After induced arterial hypotension intact autoregulation was found before as well as after treatment with nimodipine. Beneficial effects of nimodipine were found on CO 2 reactivity and CMRO 2 during hypotension that may be explained as a positive effect on cerebral ischaemia.