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Prolonged P3 latency and decreased brain perfusion in cerebellar degeneration
Author(s) -
Tachibana H.,
Kawabata K.,
Tornino V.,
Sugita M.
Publication year - 1999
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1999.tb00402.x
Subject(s) - cerebellum , neuroscience , perfusion , ataxia , psychology , cognition , latency (audio) , medicine , cerebellar cortex , audiology , cardiology , electrical engineering , engineering
Objectives ‐ To clarify the underlying mechanism of cognitive impairments in patients with cerebellar degeneration using event‐related potentials (ERPs) and regional brain perfusion measurement. Materials and methods ‐ The P3 latency of ERPs was measured during a visual discrimination task in 15 patients with idiopathic late‐onset cerebellar ataxia (ILOCA) and 10 age‐matched control subjects. Regional brain perfusion was measured by single photon emission computed tomography using N‐isopropyl‐p[ 123 I] iodoamphetamine. Results ‐ The mean P3 latency was longer in the patients than in controls. The patients showed lower perfusion in the frontal cortex and in the cerebellum than control subjects. There was a significant correlation between perfusion of the frontal cortex and cerebellum. Conclusions ‐ The results indicate that patients with ILOCA exhibit slowing of cognitive information processing and suggest that its cognitive slowing may be due to a disruption of neural circuits between the cerebellum and the frontal cortex.