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Increased apolipoprotein E4 allele frequency is associated with vascular dementia in the Hungarian population
Author(s) -
Kálmán J.,
Juhász A.,
Császár A.,
Kanka A.,
Rimanóczy Á.,
Janka Z.,
Raskó I.
Publication year - 1998
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1998.tb07288.x
Subject(s) - vascular dementia , apolipoprotein e , leukoaraiosis , allele , dementia , allele frequency , medicine , proband , alzheimer's disease , population , genetics , endocrinology , biology , gene , disease , mutation , environmental health
– The regulatory role of apolipoprotein E in lipid transport and metabolism was utilized to investigate the allelic association between the apolipoprotein E4 (apoE4) allele and vascular dementia (VD) in a selected sample of Hungarian patients with multiple deep subcortical infarcts and leukoaraiosis. Material and methods – Thirty‐four Caucasian VD cases and 79 healthy control probands were involved in this study according to the criteria of ICD‐10 and NINDS–AIREN International Workshop Diagnostic Criteria. The genomic DNA was isolated from whole blood and the apoE alleles were determined by polymerase chain reaction. Results – The E2, E3 and E4 allele frequencies in the VD group were 5%, 76%, and 19%, respectively; and significant ( P <0.03) differences were found in comparison with the data on the healthy controls (E2, 6%; E3, 87%; E4, 8%). The apoE4 allele frequency was intermediate between HC and Alzheimer's dementia group (28%). Conclusion – These results indicate that the apoE4 allele could be a risk factor not only for certain primary degenerative, but also for vascular dementias.