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Oxidative injury in the nervous system
Author(s) -
Delanty N.,
Dichter M. A.
Publication year - 1998
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1998.tb07285.x
Subject(s) - amyotrophic lateral sclerosis , medicine , nervous system , disease , epilepsy , central nervous system , pathogenesis , oxidative phosphorylation , multiple sclerosis , neuroscience , pathophysiology , oxidative stress , antioxidant , bioinformatics , pathology , immunology , biology , psychiatry , biochemistry
A free radical is a highly reactive chemical species that can react with organic macromolecules leading to cell and tissue damage and consequent functional disruption. Free radical or oxidative injury is increasingly recognized as an important factor in the pathophysiology of many human diseases, including those that affect the nervous system. This review summarizes important evidence implicating oxidative injury in the pathogenesis and progression of many important neurological disorders, including cerebrovascular disease, epilepsy, amyotrophic lateral sclerosis, and Huntington's disease. Results of controlled clinical trials of various antioxidant therapies in neurological disease performed to date are also highlighted.