Premium
Antithrombin, protein C and protein S levels in 127 consecutive young adults with ischemic stroke
Author(s) -
Douay X.,
Lucas C.,
Caron C.,
Goudemand J.,
Leys D.
Publication year - 1998
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1998.tb01731.x
Subject(s) - medicine , antithrombin , protein s , stroke (engine) , protein s deficiency , ischemic stroke , abnormality , protein c , antithrombin iii deficiency , protein c deficiency , brain ischemia , gastroenterology , ischemia , cardiology , heparin , thrombosis , venous thrombosis , mechanical engineering , psychiatry , engineering
Objectives ‐ The aim of our study was to evaluate the prevalence of antithrombin, protein C and protein S deficiencies in consecutive ischemic stroke patients under 45. Material and methods ‐ We studied 127 consecutive patients with a mean age of 34.4 years admitted for an ischemic stroke, over a 2‐year period, after exclusion of those with arterial dissection. Antithrombin, protein C and protein S levels were measured in all patients at the acute stage of the ischemic stroke and measurements were repeated in case of abnormality. Results ‐ We found abnormal levels in 9 patients. Seven had an acquired cause of deficiency (pregnancy, oestrogen, acute inflammation). Two had no obvious acquired cause of deficiency but further controls were normal. Conclusions ‐ Hereditary deficiencies of coagulation inhibitors are rare in ischemic stroke patients under 45 and their systematic detection seems to be of poor interest.