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Recovering optic neuritis during systemic cisplatin and carboplatin chemotherapy
Author(s) -
Caraceni A.,
Martini C.,
Spatti G.,
Thomas A.,
Onofrj M.
Publication year - 1997
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1997.tb00280.x
Subject(s) - optic neuritis , medicine , discontinuation , visual field , optic neuropathy , ophthalmology , carboplatin , optic nerve , visual evoked potentials , anesthesia , chemotherapy , surgery , audiology , cisplatin , multiple sclerosis , psychiatry
‐ We describe bilateral optic neuropathy in a patient affected by ovarian carcinoma treated with cis‐platin 160 mg/m 2 and carboplatin, 640 mg/m 2 . The patient was followed for 1 year, when recovery appeared. The few previous descriptions of CDDP optic nerve toxicity did not report recovery. Methods ‐ Computerized visual field, visual evoked potentials, pattern electroretinograms, full field flash electroretinograms were recorded during follow‐up. Results ‐Optic neuritis appeared 13 weeks after cis‐platin discontinuation, with right eye central scotoma; 2 days later the patient became bilaterally blind. Visual evoked potentials were initially absent, reappeared, with delayed latencies to left eye stimuli at 6 months, in both eyes at 9 months. At 1 year delayed VEPs were recorded with right eye stimuli, normal VEPs were recorded for left eye. Conclusion ‐ Cis‐platin can induce delayed optic neuritis, that can recover in 1 year.