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Acute exacerbation of multiple sclerosis increases plasma levels of S‐100 protein
Author(s) -
Missler U.,
Wandinger K. P.,
Wiesmann M.,
Kaps M.,
Wessel K.
Publication year - 1997
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1997.tb00256.x
Subject(s) - exacerbation , multiple sclerosis , medicine , disease , gastroenterology , plasma levels , immunology
Objectives ‐ To determine whether an increase in plasma concentration of S‐100 protein can serve as a marker for acute exacerbation of multiple sclerosis. Material and methods ‐ The plasma level of S‐100 protein was investigated in 28 patients suffering from multiple sclerosis. Of these, 17 patients were admitted for acute exacerbation and 11 patients had a stable disease with no clinical signs for acute exacerbation. S‐100 protein concentrations in plasma were determined with an immunofluorometric sandwich assay. Results ‐ Plasma concentrations were significantly elevated in patients who were examined within 7 days after the onset of acute exacerbation ( n =6). S‐100 levels of patients 8 to 28 days after the onset of acute exacerbation ( n =11) did not differ from healthy controls ( n =120). Eleven patients with multiple sclerosis without acute exacerbation had moderately elevated plasma levels. Conclusion ‐ The plasma concentration of S‐100 protein is a sensitive although unspecific indicator of neuronal damage and may be of use as a marker of disease activity in multiple sclerosis.